C. Statements 3 and 4 are MOST associated with the 'optimize and automate' guiding principle. The 'optimize and automate' guiding principle is focused on improving efficiency and reducing waste by automating processes wherever possible. It encourages organizations to continually review and improve their processes and services to ensure that they are operating as efficiently and effectively as possible. Statement 3 is directly related to the 'optimize and automate' guiding principle, as it suggests that organizations should consider whether technology could improve the efficiency of manual processes. This is a key aspect of the principle, as it encourages organizations to automate manual processes wherever possible in order to increase efficiency and reduce waste. Statement 4 is also related to the 'optimize and automate' guiding principle, as it highlights the importance of understanding the organization's objectives when assessing the impact of potential improvements. This is important because it ensures that any improvements made are aligned with the organization's goals and objectives, and are not implemented in a way that creates unnecessary waste or inefficiency.

The statements most associated with the 'optimize and automate' guiding principle are: complex systems should be designed with an understanding of how the components' parts are related, and organizations should consider whether technology could improve the efficiency of manual processes. Understanding interactions within systems is crucial for optimization and automation, and evaluating the potential of technology to enhance efficiency aligns with this principle. Therefore, the statements most related to 'optimize and automate' are focused on these aspects.